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Maintaining proper airflow in a biological safety cabinet (BSC) is essential for ensuring the safety of personnel from potentially hazardous biological materials, preserving specimen integrity by preventing contamination, and adhering to correct airflow practices to support compliance with regulatory standards. OneLab VR's new Biological Safety Cabinet: Start-up and Airflow scenario will help learners gain the knowledge to work safely in a BSC. More information can be found at https://reach.cdc.gov. Note: This video contains a voice over that was generated by Colossyan NEO2.